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Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells

The so-called hyperbaric oxygen therapy (hyperbaric oxygen therapy,HBOT) refers to the treatment of increasing dissolved oxygen in human tissues by delivering 100% pure oxygen in an environment higher than an atmospheric pressure. We know that at the cellular level, there are two key signs of the aging process: telomere shortening and cell senescence. Telomeres are nucleotide repeats at the ends of chromosomes that maintain genomic stability. They shorten during mitosis and shorten by about 20-40 bases a year in the human body. When telomeres reach critical length, cells enter a state of aging or death.

Telomere length is associated with different diseases, and studies have shown that short telomeres are associated with a higher risk of death. Cell senescence is a state of cell cycle stagnation, senescent cells will accumulate with aging, and their accumulation will in turn aggravate senescence. To resist these two changes, a lot of drugs or lifestyle interventions have been studied, so what are the magic methods of hyperbaric oxygen therapy mentioned today? This is about to mention a very interesting hyperoxia-hypoxia paradox.

Intermittent hyperoxia exposure can cause adaptive responses, such as increasing the expression of antioxidant-related genes and adapting to increased reactive oxygen species by increasing antioxidants. Because the half-life of antioxidants is longer than that of active oxygen, the antioxidant activity continues to increase after returning to normal oxygen levels.In addition, intermittent hyperoxia exposure can induce many physiological responses during hypoxia, such as hypoxia inducible factor (HIF) release, and further induce cell cascade responses, including vascular endothelial growth factor release, angiogenesis, mitochondrial biogenesis, stem cell mobilization and so on.

All these may help fight aging. Recently, a scientific team from Israel conducted the study at Aging. Participants were asked to receive pure oxygen through a mask at two atmospheres for 90 minutes at a time and a five-minute break every 20 minutes. The treatment was carried out five times a week for a total of 60 times, that is, for three months. After the 30th treatment, 60 treatments, and 1-2 weeks after all the treatments were completed, the blood samples of the participants were taken for analysis.

The results of clinical studies showed that when the healthy elderly were treated with hyperbaric oxygen for 60 times, the telomeres of peripheral blood mononuclear cells (PMBC) of the participants were significantly prolonged by more than 20%, and the aging cells also decreased by up to 37%.




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